Conservative treatment of Peyronie's disease

Conservative treatment of Peyronie's disease possible in the acute stage, and in the early stages. Pills and injections can relieve the pain, stop the inflammation. Get rid of the external signs of the curvature of the member is possible only by injection into the plaque or surgically.

Peyronie's Disease

The first symptoms of penile curvature, it is necessary to consult a specialist. The doctor andrologist will select for you the optimal solution to the problem. After diagnosis perhaps the appointment of conservative treatment.

How to cure Peyronie's disease without surgery: principles of treatment

The basic principles and objectives of conservative treatment of Peyronie's disease are:

  • removal of the acute inflammatory process, which reduces its surface area and the intensity of the tunica albuginea of the penis;
  • to reduce the pain syndrome;
  • to prevent the formation of plaques;
  • landing area, or (if possible) complete dissolution of the plaque;
  • may require conservative treatment of Peyronie's after surgery .

Perhaps the use of physiotherapy, oral medications, topical therapy, injection therapy. Cure Peyronie's disease in the early stages it can only help in the complex treatment, which includes several approaches.

Drugs for the treatment of Peyronie's disease

There are several drugs that have passed clinical trials and is effective in Peyronie's disease. Each of them provides its effect, while focused on different stages of pathogenesis, which requires the integrated application.

Only when internal examination and Doppler ultrasound of the penis, a doctor may suggest what type of treatment can be effective (much depends on the causes of the disease).

Treatment of Peyronie's disease without surgery paraaminobenzoic

This medication has a number of useful therapeutic effects:

  • to prevent the proliferation of fibroblasts;
  • to reduce the secretion of mucopolysaccharides and glycosaminoglycans;
  • increases the absorption of oxygen to the tissues of the penis;
  • prevent fibrinogenez.
Injection

Injection

The use of the subject is adult men with Peyronie's disease with palpable plaque and curvature deformity of at least 30 degrees at the beginning of treatment. Is injected directly into the plaque. Each injection helps to reduce and destroy plaque and help straighten the curvature of penis, called Peyronie's disease.

Vitamin E for Peyronie's disease

Vitamin E, a fat-soluble antioxidant that inactivates free radicals, which are impregnated with nitric oxide (NO), which maintains the elevated active NOT proper healing. By limiting oxidative stress, it may also have anti-inflammatory effect. It was first described for the treatment of Peyronie's disease in 1948 and thanks to its low price and availability remains the most commonly prescribed oral agent for the treatment of PD. Despite its use over the last seven decades, several placebo-controlled studies have shown no significant improvement in pain, curvature, the tile size, or to restore erectile. In 1983, Pryor and Farrell completed the double-blind, placebo-controlled study of vitamin E in 40 patients with PD and found no significant improvement in plaque size or penile curvature. In addition, newer research conducted in 2007 provided the largest study of vitamin E for the treatment of Peyronie's disease. The authors compared vitamin E alone and in combination with L-carnitine with placebo in 236 men with early chronic PD; is classified as a patient with pain during erection, penile curvature not affecting vaginal penetration, painless palpabile scar, damage hyper echogenic ultrasound of the penis, without calcification, and total area of plaques <2 cm2.

Group 1 (58 men) received 300 mg vitamin E orally twice a day.

Group 2 (59 men) received propionyl-L-carnitine 1 g orally two times a day.

Group 3 (60 men) received 300 mg vitamin E orally twice a day, and 1 g of propionyl-L-carnitine orally twice a day.

Group 4 received the same treatment with placebo during 6-month probationary period. After treatment no significant change in the reducing curvature of the penis between the four groups (P = 0,9), and also reduces the size of plaques (P = 0.1) (12).

Cream

Despite the lack of evidence to support the effectiveness of vitamin E, it is still often prescribed prescribed in combination with other therapies with the hope of synergistic role. The most common side effects with use of vitamin E are nausea, vomiting, diarrhea and increased risk of developing prostate cancer.

Heparin ointment Peyronie's disease

Heparin ointment reduces inflammation of the tissues of the penis, expand blood vessels, thus optimizing the blood stream.

It can be shown the pain in the acute stage. The therapeutic effect of the ointment is.

Omega-3 fatty acids

Omega-3 was tested on Peyronie's disease (due to anti-inflammatory properties)

In 2009, he published a study, randomized, double-blind study of omega-3 compared to placebo.

A total of 224 patients with early chronic-stage PD were randomized to the dose of 1.84 g daily supplement of omega-3 compared with placebo at 6 months.

Unfortunately, there is no significant improvement in plaque volume, penile curvature, pain during erection and erectile function. Currently, there are no data confirming the positive effects of omega-3 early chronic stages of Peyronie's disease.

Omega 3 is beneficial for any person. You can take omega-3 without prescription. But there was no treatment effect is.

Omega 3

Phosphodiesterase type-5 inhibitors (inhibitors PDE-5)

Even though inhibitors PDE-5 is generally considered the treatment of erectile dysfunction (ED), recent studies have shown its potential use in the treatment of Peyronie's disease patients with or without ED. PDE5 inhibitors increase cyclic guanosine monophosphate (cGMP) by inhibiting its degradation of GMP GMP. Increase the level of cGMP and NO protein synthesis and deposition of collagen is inhibited, and the apoptosis of fibroblasts and myo-fibroblasts.

Due to this property inhibit the PDE-5 may be useful in remodeling the scars.

At the moment, there was only one study, which did seem to improve the scar formations of the penis. But all of the patients were without significant plaques. And the curvature was less than 10%.

At the moment, PDE 5 is not configured. Maybe later, when there will be new clinical trials and found to have a therapeutic effect.

L-arginine

L-arginine helps to reduce the fibroblasts for apoptosis. The mechanism underlying L-arginine is considered an anti-fibrotic agent.

The researchers measured plaque in the penis in rats treated with inhibitors PDE-5 and l-arginine. Similar to inhibit PDE-5, L-arginine, there was a significant decline in the size of plaques and the ratio of collagen fibroblasts. Later studies have shown that arginine is also a protective effect against the formation of scar tissue, when exposed to the penis of rats.

In 2012, a significant trend towards improvement in curvature in patients with PD treatment of the penis along with vnutricletocnam verapamil, oral L-arginine and oral pentoxifylline (PTX). Although this study has many variables that can contribute to improve curvature, it was one of the few human studies with L-arginine used in the treatment of PD. Because of these results, L-arginine may be a viable treatment option for BP, but additional studies are needed to people.

L-arginine

L-arginine can be assigned complex conservative therapy.

Peyronie's disease without surgery: local administration of medicines

This method is more effective to fix the curvature of the member than in the oral resources. The injections are given under local anesthesia. The procedure should be performed only by an experienced specialist.

Of drugs imported into the tunica albuginea of the penis (directly on the plaque and scar). The procedure should be carried out with caution, because there is a big risk to aggravate the pathological process, increase inflammation, the number and size of plaques.

The possibility of treatment of injections depends on the size of the plaque, its location and the General condition of the patient. If the injection is a long process, during surgical treatment of curvature can be disposed of at one time. Internal consultation to determine the best treatment option for each patient.